Effects of fucoidan from Fucus vesiculosus (FvF) on the serum and liver lipid profile in high-fat diet (HFD) and streptozotocin (STZ)-induced metabolic syndrome (MetS) mice. (a) Serum triacylglycerol (TG); (b) Serum total cholesterol (TC); (c) Serum low density lipoprotein-C (LDL-C); (d) Serum high density lipoprotein-C (HDL-C); (e) lipid accumulation in liver tissue characterized by Oil Red O staining (100×). C, mice were fed a normal diet; M, mice were fed a HFD; Metf, mice were fed a HFD with 225 mg/kg/day metformin; FvF-L, mice were fed a HFD with 20 mg/kg/day FvF; FvF-H, mice were fed a HFD with 100 mg/kg/day FvF. Data are expressed as the mean ± SEM. Differences were assessed by ANOVAs and statistical results are denoted as follows: * p < 0.05 versus the control group; # p < 0.05 versus the model group.