Figure 6.

Effects of fucoidan from Fucus vesiculosus (FvF) on the blood glucose related physiological indexes in high-fat diet (HFD) and streptozotocin (STZ)-induced MetS mice. (a) Fasting blood glucose; (b) Random blood glucose; (c) Glycated hemoglobin (GHb) content; (d) Homeostatic model assessment for insulin resistance (HOMA-IR), calculated by fasting blood glucose (mmol L⁻¹) * fasting insulin (mU/L)/22.5; (e) Oral glucose tolerance test (OGTT) was conducted at the ninth week. C, mice were fed a normal diet; M, mice were fed a HFD; Metf, mice were fed a HFD with 225 mg/kg/day metformin; FvF-L, mice were fed a HFD with 20 mg/kg/day FvF; FvF-H, mice were fed a HFD with 100 mg/kg/day FvF. Data are expressed as the mean ± SEM. Differences were assessed by ANOVAs and statistical results are denoted as follows: * p < 0.05 versus the control group; # p < 0.05 versus the model group.