Figure 1.

A, Shows the normally dense and homogeneous pattern of sweat drop imprints obtained in the patients after pilocarpine stimulation by dynamic sweat test. Consistently, B shows the normal pattern of sweat gland innervation by post‐ganglionic sudomotor nerves. Confocal micrographs of glabrous (C, D) and hairy (E, F) skin biopsy sections from the patient (C, E) and an age‐matched healthy subject (D, F). In C, note the complete lack of Meissner corpuscles and in E the severe reduction of intraepidermal nerve fiber density, compared to D and F, respectively. In green, nerve fibers marked with the pan neuronal marker protein‐gene‐product 9.5; in red, blood vessels and basement membranes marked with collagen IV; in blue, endothelia and keratinocytes marked with ULEX europaeus. Scale bar equals 100 μm