Figure 5.

Effect of IL‐6 on VEGF gene and protein expression in hASCs under normoxia or hypoxia. (a,b) Hypoxia enhanced VEGF expression in hASCs at Day 2 and 7. (a) IL‐6 at 10 ng/ml enhanced VEGF expression under normoxia at Day 2. (b) IL‐6 at 1 ng/ml decreased VEGF expression under hypoxia at Day 7. (c) Hypoxia but not IL‐6, enhanced VEGF protein concentration. Results are mean ± SD from n = 3 (duplicate wells of three independent experiments). *Significant effect of IL‐6 under normoxia or hypoxia, p < 0.05. hASC: human adipose stem cell; IL: interleukin; VEGF: vascular endothelial growth factor [Color figure can be viewed at wileyonlinelibrary.com]