Figure 1.

A screen of novel selective CB₂R agonists to determine the most efficacious ligand in reducing leukocyte-endothelial adhesion in the iridial microcirculation during EIU in BALB/c mice. The bar graph represents the mean number of adherent leukocytes 6 h after intravitreal injection of: Saline (control) + topical vehicle (Tocrisolve, n = 6); lipopolysaccharide (LPS) (250 ng) + topical vehicle (n = 6); LPS + topical HU910 (1.5% w/v; n = 6); LPS + topical RO6871304 (1.5% w/v; n = 6); or LPS + topical RO6871085 (1.5% w/v; n = 6). Data are presented as mean ± SD. One-way ANOVA with Tukey’s for multiple comparisons; * p < 0.05 compared to LPS + vehicle.