Figure 2.

RO6871304 exerts its anti-inflammatory effects through CB₂R. CB₂R^-/- mice with EIU exhibit increased iridial leukocyte-endothelial adhesion compared to wild-type (WT). Bar graph represents the mean number of adherent leukocytes in WT or CB₂R^-/- mice 6 h following intravitreal injection of LPS and topical treatment with either vehicle (Tocrisolve, n = 7) or RO6871304 (1.5% w/v; n = 6). Data are presented as mean ± SD. One-way ANOVA with Dunnett; * p < 0.05 compared to LPS + vehicle in WT mice.