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. 2019 Sep 13;24(18):3338. doi: 10.3390/molecules24183338

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CB₂R activation reduces neutrophil migration towards chemoattractant. (A) Bar graph represents the mean number of neutrophils from WT or CB₂R^-/- mice pre-treated with various concentrations of the CB₂R agonist, RO6871304, that migrated to the lower chamber of a Boyden chamber setup when using CXCL2 (10⁻⁸ M) as a chemoattractant. Neutrophils were counted from 12 random microscopic fields of view per well. (B) Bar graph represents the mean number of neutrophils from WT mice pre-treated with various concentrations of the CB₂R inverse agonist, RO6851228, or vehicle (0.01% DMSO) that migrated in the Boyden chamber setup. Data are presented as the mean neutrophil migration per microscopic field of view ± SD from at least three independent experiments conducted in triplicate each. One-way ANOVA with Dunnett; ** p < 0.01 compared to WT neutrophils + CXCL2 + vehicle.