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. 2019 Sep 13;24(18):3338. doi: 10.3390/molecules24183338

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CB₂R activation in neutrophil-depleted EIU mice with accompanying leukocyte adoptive transfer reduces leukocyte adhesion in the iridial microcirculation. Representative intravital microscopy (IVM) images of the iridial microcirculation of neutrophil-depleted mice showing the number of adoptively-transferred adherent leukocytes [calcein-acetoxymethyl ester (AM) pre-labeled] 6 h after intravitreal saline (A) or LPS (B). Arrows indicate adherent leukocytes. Scale bar = 100 μm. (C) bar graph represents the mean number of adoptively-transferred WT leukocytes adherent to the iris microcirculation 6 h after EIU induction with LPS injection or saline control in neutrophil-depleted WT mice treated topically with vehicle (Tocrisolve) or RO6871304 (1.5% w/v). n = 6-8; one-way ANOVA with Dunnett; **** p < 0.0001 compared to LPS + vehicle. (D) bar graph represents the mean number of adoptively-transferred WT leukocytes adherent to the iris microcirculation 6 h after EIU in neutrophil-depleted CB₂R^-/- mice treated topically with vehicle (Tocrisolve) or RO6871304. n = 6–8; two-tailed unpaired t-test; **** p > 0.05 compared to LPS + vehicle.