Table 1.
Relative cell viabilities and apoptosis rate.
| Drugs | Apoptosis Rate [%] at Day 2 |
Cell Viability [%] at Day 7 |
Drugs | Apoptosis Rate [%] at Day 2 |
Cell Viability [%] at Day 7 |
||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| 1_DMSO | 0.69 | 0.01 | 99.42 | 9.16 | 37_Cabozantinib | 4.49 | 0.59 | 33.38 | 3.01 |
| 2_AEE788 | 0.34 | 0.10 | 61.57 | 4.03 | 38_Foretinib | 0 | 0 | 20.45 | 3.13 |
| 3_Afatinib | 0 | 0 | 49.98 | 2.47 | 39_Ibrutinib | 0 | 0 | 83.26 | 7.65 |
| 4_BMS-599626 | 0 | 0 | 84.89 | 7.01 | 40_Vemurafenib | 0 | 0 | 38.29 | 1.93 |
| 5_Erlotinib HCl | 0 | 0 | 47.45 | 4.65 | 41_Trametinib | 0 | 0 | 24.93 | 1.90 |
| 6_Dacomitinib | 0.89 | 0.19 | 87.11 | 10.32 | 42_LDE225 | 0 | 0 | 80.57 | 11.47 |
| 7_Gefitinib | 0 | 0 | 96.42 | 7.42 | 43_LDK378 | 0 | 0 | 17.12 | 1.48 |
| 8_Lapatinib | 0 | 0 | 100.23 | 2.22 | 44_LEE011 | 0 | 0 | 71.75 | 0.32 |
| 9_Neratinib | 0 | 0 | 65.71 | 0.96 | 45_Nilotinib | 0 | 0 | 98.56 | 3.70 |
| 10_CI-1033 | 0 | 0 | 77.57 | 5.42 | 46_Olaparib | 0 | 0 | 59.86 | 6.60 |
| 11_CO-1686 | 0 | 0 | 17.64 | 2.53 | 47_Panobinostat | 6.66 | 1.44 | 27.42 | 3.96 |
| 12_BKM120 | 0.92 | 0.35 | 16.56 | 2.60 | 48_Pazopanib HCl | 0 | 0 | 33.76 | 5.86 |
| 13_BYL719 | 2.32 | 0.22 | 34.03 | 2.95 | 49_PD 0332991 | 0 | 0 | 92.83 | 30.81 |
| 14_XL147 | 0 | 0 | 23.57 | 4.21 | 50_PF-04449913 | 0 | 0 | 89.99 | 9.74 |
| 15_Everolimus | 0 | 0 | 71.49 | 6.86 | 51_Sotrastaurin | 0 | 0 | 102.03 | 8.52 |
| 16_AZD2014 | 0 | 0 | 24.98 | 1.68 | 52_Sunitinib Malate | 0 | 0 | 25.59 | 17.95 |
| 17_PF-05212384 | 0 | 0 | 17.38 | 1.92 | 53_Tandutinib | 0 | 0 | 91.14 | 7.34 |
| 18_XL765 | 0 | 0 | 71.00 | 8.48 | 54_Tivozanib | 0 | 0 | 30.03 | 16.26 |
| 19_BEZ235 | 0 | 0 | 22.00 | 2.73 | 55_Vismodegib | 1.14 | 0.26 | 84.62 | 10.29 |
| 20_AZD5363 | 0 | 0 | 44.08 | 7.03 | 56_ PHA-665752 | 0 | 0 | 84.60 | 3.94 |
| 21_ABT-199 | 0.61 | 0.37 | 49.72 | 7.19 | 57_Dabrafenib | 0 | 0 | 73.82 | 7.10 |
| 22_ABT-888 | 0.00 | 0.00 | 88.16 | 16.55 | 58_Regorafenib | 0 | 0 | 21.79 | 9.13 |
| 23_AUY922 | 0.76 | 0.15 | 15.38 | 1.60 | 59_Bosutinib | 0 | 0 | 36.95 | 21.63 |
| 24_Axitinib | 2.12 | 0.10 | 56.63 | 2.39 | 60_Carfilzomib | 8.86 | 1.83 | 22.05 | 0.61 |
| 25_AZD4547 | 0.87 | 0.31 | 38.02 | 8.25 | 61_Ruxolitinib | 1.60 | 0.73 | 45.07 | 7.13 |
| 26_AZD6244 | 1.12 | 0.23 | 33.45 | 3.32 | 62_Vandetanib | 0 | 0 | 88.58 | 3.39 |
| 27_LGK-974 | 0 | 0 | 80.21 | 2.08 | 63_TMZ | 0 | 0 | 45.39 | 6.55 |
| 28_BGJ398 | 0 | 0 | 99.67 | 5.23 | 64_Amorolfine | 0 | 0 | 86.03 | 5.40 |
| 29_Bortezomib | 0.33 | 0.14 | 19.77 | 17.33 | 65_Mevastatin | 0 | 0 | 57.40 | 2.01 |
| 30_Cediranib | 8.19 | 1.17 | 27.19 | 3.64 | 66_Amiodarone | 0 | 0 | 95.74 | 1.28 |
| 31_Crizotinib | 0.94 | 0.06 | 40.77 | 3.93 | 67_Fluvastatin Na | 0 | 0 | 97.19 | 11.40 |
| 32_Dasatinib | 1.25 | 0.46 | 55.20 | 5.23 | 68_Mycophenolic acid | 0.98 | 0.52 | 43.50 | 1.93 |
| 33_Dovitinib | 0 | 0 | 11.78 | 1.08 | 69_Raloxifene HCl | 0 | 0 | 100.19 | 14.60 |
| 34_Imatinib | 0 | 0 | 115.71 | 8.27 | 70_Astemizole | 0 | 0 | 95.88 | 10.87 |
| 35_INCB28060 | 0 | 0 | 83.07 | 8.93 | 71_Fenretinide | 1.29 | 0.11 | 47.24 | 20.81 |
| 36_LY2835219 | 0 | 0 | 57.65 | 4.79 | - | - | - | - | - |