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. 2019 Sep 11;24(18):3308. doi: 10.3390/molecules24183308

Figure 5.

Figure 5

Higher level regulatory mechanisms of GEFs: Positive feedback loops of Rac/RasGEF SOS and Cytohesin3, regulation of Vav1 by the PH-DH module, and regulation of EPAC2 by the second messenger. The right panels show models for each regulatory mechanism.