Figure 6.

Local protein unfolding and refolding mechanism: (A) Structures of Rab8 in a complex with MSS4 and GDP-bound form and (B) Structures of RhoA in a complex with SmgGDS and GDP-bound form. The nucleotide recognition regions (P loop, switch I, and switch II) are almost ordered in the unbound form, but these regions are largely disordered in both proteins upon binding of the regulator. Disordered regions are shown as dashed lines. The color scheme and other descriptions follow those of Figure 1B.