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. 2019 Mar 22;106(2):383–390. doi: 10.1002/cpt.1371

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© 2019 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Projected asthma exacerbation risk by treatment regimen, antidrug antibody (ADA) status, and age group from clinical trial simulations.^a Q4W, every 4 weeks; Q8W, every 8 weeks. ^aOne hundred trial simulations with 500 patients for each scenario. ^bThe prediction interval for adolescents was wider than that for adults because of the smaller numbers enrolled in the SIROCCO and CALIMA trials compared with adult patients. [Colour figure can be viewed at wileyonlinelibrary.com]