Table 2.
Parameter Estimates of the Final Model and Their Corresponding Bootstrap Estimates
| Parameter | Final Model Estimate (RSE%) [Shrinkage] | Bootstrap Estimate (95%CI) |
|---|---|---|
| Fixed effects | ||
| CL [L/h] = CLp | 0.0737 (13%) | 0.0787 (0.0550–0.102) |
| CLi = CLp × (WTi/Median WT)ƟWT | ||
| ƟWT | 1.69 (10%) | 1.67 (0.406–2.47) |
| V [L] = Vp | ||
| Vi = Vp × (WTi/Median WT) | 1.03 (21%) | 1.11 (0.877–1.37) |
| Interindividual variability (η) | ||
| On CL [%] | 91.9 (15%) [8%] | 96.6 (67.5–128) |
| On V [%] | 67.2 (16%) [17%] | 72.7 (47.4–96.8) |
| Residual variability | ||
| Proportional (%) | 33.8 (16%) | 34.0 (28.6–39.4) |
| Additive (µg/L) | 0.218 (56%) | 0.283 (0.0800–0.585) |
CL indicates clearance; i, individual; p, population mean value of a parameter for an individual with body weight of 1.12 kg; RSE, residual standard error; V, central volume of distribution; WT, actual body weight (median WT = 1.12 kg); ƟWT, exponent for influence of WT on CL .
Bootstrap convergence rate was 83.1%.