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. 2019 Apr 29;248(4):476–487. doi: 10.1002/path.5274

Figure 3.

PATH-5274-FIG-0003-c

YWHAZ amplification/overexpression negatively regulates signaling pathways in caspase‐mediated apoptosis. (A) Gene set enrichment analysis was performed using mRNA expression data from the TCGA group. Two pathways, apoptotic cleavage of cellular proteins and innate immune system, were found associated with YWHAZ amplification/overexpression in UCUBs. (B) Scatter plot shows genes significantly (−log(p value) > 5.0) up‐ (log ratio > 0.3) or downregulated (log ratio < −0.3) along with YWHAZ amplification/overexpression (right upper panel). The functional protein interaction network of YWHAZ‐associated genes was analyzed using the STRING database (http://string‐db.org/) (left). Four major pathways were found to be involved in YWHAZ amplification/overexpression in UCUBs: regulation of endopeptidase activity, activation of cysteine‐type endopeptidase activity, endopeptidase activity involved in apoptotic process, and apoptotic signaling pathway with false discovery rates (q values) < 1.00 E‐03. (C) Gene expression heat map of 10 key genes involved in endopeptidase‐mediated cell death in UCUBs with or without YWHAZ amplification. Genetic and mRNA expression data were from the TCGA group.