Table 1.

Correlation between YWHAZ amplification/protein overexpression and various clinicopathological factors

		14‐3‐3 ζ/δ (n = 295)			YWHAZ gene (n = 289)
Parameters	Category	No. of case	Low (0 to ∼2+)	High (3+ to ∼4+)	P value	No. of cases	No amp.	Amp.	P value
Gender	Male	216	161	55	0.282	213	122	91	0.416
	Female	79	64	15	76	48	28
Age (years)	<60 years	81	66	15	0.222	80	48	32	0.894
	≧60 years	214	159	55	209	122	87
Primary tumor (T)	Ta	84	74	10	<0.001***	83	59	24	<0.001***
	T1	88	75	13	85	56	29
	T2–T4	123	76	47	121	55	66
Nodal status (N)	N0	266	210	56	0.002**	260	109	101	0.027*
	N1–N2	29	15	14	29	11	18
Histological grade	Low grade	56	48	8	0.080	55	38	17	0.095
	High grade	239	177	62	234	132	102
Vascular invasion	Absent	246	195	51	0.010*	240	144	96	0.426
	Present	49	30	19	49	26	23
Perineurial invasion	Absent	275	213	62	0.100	269	160	109	0.482
	Present	20	12	8	20	10	10
Tumor necrosis	Absent	191	148	43	0.567	186	112	74	0.535
	Present	101	77	27	103	58	45
Mitotic activity (10 HPF)	<10	139	115	24	0.019*	135	92	43	0.003**
	≥10	156	110	46	154	78	76

Amp, amplification. Statistically significant:

^* p < 0.05

^** p < 0.01

^*** p < 0.001.