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. 2019 Sep 5;24(18):3229. doi: 10.3390/molecules24183229

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Composition of the anti-malarial model tablets. 100% refers to the nominal content in the original Riamet^® tablet, which are 120 mg lumefantrine and 20 mg artemether, corresponding to 60 wt% lumefantrine, 10 wt% artemether, and 30 wt% filling excipient hypromellose in the tablet. The total mass of each tablet is 200 mg. (A) Lu100Ar100: Content of nominal 100% lumefantrine and nominal 100% artemether (60 wt% lumefantrine, 10 wt% artemether and 30 wt% filling excipient hypromellose in the tablet). (B) Lu50Ar100: Content of nominal 50% lumefantrine and nominal 100% artemether (30 wt% lumefantrine, 10 wt% artemether, and 60 wt% filling excipient hypromellose in the tablet). (C) Lu100Ar0: Content of nominal 100% lumefantrine and nominal 0% artemether content (40 wt% lumefantrine and 60 wt% filling excipient hypromellose in the tablet). (D) Lu0Ar100: Content of nominal 0% lumefantrine and nominal 100% artemether content (10 wt% artemether and 90 wt% filling excipient hypromellose in the tablet).