Figure 1.

Effects of loratadine (0.5–50 mg/kg p.o.) on the composition and mineralization of the L-4 vertebra in young male rats. Results are presented as median (line), interquartile range (box), and minimum and maximum values (whiskers); n=8–10. Loratadine at doses of 0.5 mg/kg, 5 mg/kg, or 50 mg/kg was administered orally, once daily for 4 weeks. Kruskal–Wallis test followed by Mann–Whitney U test were used for statistical evaluation of loratadine effect in comparison with the control rats. *P<0.05, **P<0.01 – in comparison with the control rats.

Abbreviations: C, control rats; L0.5, rats treated with loratadine at a dose of 0.5 mg/kg p.o.; L5, rats treated with loratadine at a dose of 5 mg/kg p.o.; L50, rats treated with loratadine at a dose of 50 mg/kg p.o.