Table 4.
Effects of loratadine (0.5–50 mg/kg p.o.) on mechanical properties of the tibial metaphysis in young male rats
| Parameter/group | C | L0.5 | L5 | L50 |
|---|---|---|---|---|
| Young’s modulus (MPa) | 577 (428–862) | 560 (447–915) | 662 (559–961) | 861 (452–1010) |
| Maximum load (N) | 36.1 (29.2–38.5) | 34.4 (28.4–38.2) | 32.4 (27.6–44.1) | 43.0 (30.6–62.2) |
| Displacement for maximum load (mm) | 0.922 (0.642–1.971) | 1.081 (0.713–2.007) | 1.211 (0.700–1.735) | 1.319 (0.591–2.001) |
| Energy for maximum load (mJ) | 21.0 (13.0–50.0) | 24.5 (14.0–57.0) | 26.0 (13.0–49.0) | 37.0 (13.0–61.0) |
| Stress for maximum load (MPa) | 19.0 (13.5–23.8) | 18.2 (15.2–22.1) | 19.1 (13.8–25.7) | 23.1 (16.0–33.8) |
| Fracture load (N) | 27.3 (23.2–35.5) | 31.0 (20.2–36.4) | 29.0 (26.8–34.6) | 34.4 (27.0–42.3) |
| Displacement for fracture load (mm) | 2.001 (1.476–2.006) | 2.002 (1.585–2.007) | 2.001 (1.498–2.004) | 2.001 (1.713–2.002) |
| Energy for fracture load (mJ) | 51.0 (42.0–56.0) | 52.0 (37.0–61.0) | 51.0 (46.0–63.0) | 63.0 (47.0–84.0) |
| Stress for fracture load (MPa) | 15.1 (11.5–23.4) | 16.3 (10.7–22.1) | 15.9 (13.7–19.8) | 17.5 (15.8–22.9) |
Notes: Results are presented as median (min–max); n=8–10. Loratadine at doses of 0.5 mg/kg, 5 mg/kg, or 50 mg/kg was administered orally, once daily for 4 weeks. Kruskal–Wallis test followed by Mann–Whitney U test were used for statistical evaluation of loratadine effect in comparison with the control rats.
Abbreviations: C, control rats; L0.5, rats treated with loratadine at a dose of 0.5 mg/kg p.o.; L5, rats treated with loratadine at a dose of 5 mg/kg p.o.; L50, rats treated with loratadine at a dose of 50 mg/kg p.o.