Table 3.
Sarcoma patient characteristics and management across age groups
| Age | Age at diagnosis (% of the age groups within the series) | ||||||
|---|---|---|---|---|---|---|---|
| 0–17 n = 367 (2.9%) | 18–30 n = 772 (6.0%) | 31–60 n = 4,451 (34.7%) | 61–79 n = 5,789 (45.1%) | 80–90 n = 1,343 (10.5%) | >90 n = 113 (0.6%) | p value1 | |
| Histology | |||||||
| Complex genomics | |||||||
| UPS | 2 (0.5%) | 23 (2.9%) | 427 (9.6%) | 774 (13.4%) | 273 (20.3%) | 40 (35·4%) | <0.001 |
| LMS | 7 (1.9%) | 44 (5.7%) | 1,038 (23.3%) | 1,359 (23.5%) | 314 (23.4%) | 16 (14·2%) | <0.001 |
| Myxofibrosarcoma | 2 (0.5%) | 8 (1.0%) | 214 (4.8%) | 445 (7.7%) | 135 (10.1%) | 14 (12·4%) | <0.001 |
| Angiosarcoma | 8 (2.2%) | 35 (4.5%) | 194 (4.4%) | 324 (5.6%) | 105 (7.8%) | 12 (10·6%) | <0.001 |
| DDLPS | 0 (0%) | 10 (1.3%) | 412 (9.3%) | 892 (15.4%) | 192 (14.3%) | 11 (9·7%) | <0.001 |
| Undifferentiated sarcoma | 11 (2.9%) | 40 (5.2%) | 245 (13.2%) | 369 (6.4%) | 103 (7.7%) | 10 (8·8%) | 0.002 |
| Pleomorphic RMS | 0 (0.0%) | 6 (0.8%) | 23 (0.7%) | 32 (0.5%) | 6 (0.4%) | 1 (0.9%) | 0.64 |
| GIST | 2 (0.5%) | 20 (2.6%) | 496 (11.1%) | 859 (14.8%) | 113 (8.4%) | 6 (5.3%) | <0.001 |
| Translocation sarcoma | |||||||
| Ewing | 85 (23.2%) | 94 (12.2%) | 93 (2.1%) | 34 (0.5%) | 5 (0.4%) | 1 (0·9%) | <0.001 |
| Myxoid LPS | 7 (1.9%) | 61 (7.9%) | 307 (6.8%) | 99 (1.7%) | 10 (0.7%) | 1 (0·9%) | <0.001 |
| Synovial sarcoma | 39 (10.6%) | 144 (18.6%) | 322 (7.2%) | 114 (1.9%) | 16 (1.2%) | 1 (0·9%) | <0.001 |
| Other/not specified | 203 (55.3%) | 287 (37.2%) | 1,080 (24.2%) | 488 (8.4%) | 71 (5.3%) | 0 (0%) | <0.001 |
| Gender | |||||||
| Female | 153 (41.7%) | 362 (46.9%) | 2,355 (52.9%) | 2,759 (47.7%) | 654 (48.7%) | 62 (54.9%) | <0.001 |
| Male | 214 (58.3%) | 410 (51.3%) | 2096 (47.1%) | 3,030 (52.3%) | 689 (51.3%) | 51 (45.1%) | |
| Grade | |||||||
| 1 | 9 (2.5%) | 68 (8.8%) | 513 (11.5%) | 418 (7.2%) | 78 (5.8%) | 6 (5.3%) | <0.001 |
| 2 | 28 (7.6%) | 130 (16.8%) | 1,081 (24.3%) | 1,541 (26.6%) | 353 (26.3%) | 24 (21.2%) | |
| 3 | 136 (37.1%) | 195 (25.3%) | 1,219 (27.4%) | 1,735 (30.0%) | 515 (38.3%) | 39 (34.5%) | |
| UNK/NA | 194 (52.8%) | 379 (49.1%) | 1,638 (36.8%) | 2095 (36.2%) | 397 (29.6) | 44 (38.9%) | |
| Depth | |||||||
| Deep | 176 (47.9%) | 488 (63.2%) | 3,523 (79.2%) | 4,361 (75.3%) | 894 (66.5%) | 63 (55.7%) | <0.001 |
| Superficial | 15 (4.1%) | 70 (9.1%) | 543 (12.2%) | 896 (15.5%) | 349 (26.0%) | 45 (39.8%) | |
| Unknown | 176 (48.0%) | 214 (27.7%) | 385 (8.6%) | 532 (9.2%) | 240 (17.8%) | 5 (4.4%) | |
| Size in mm (median) | 69.1 | 72.7 | 70.2 | 75.5 | 69.7 | 8.0 | 0.002 |
| Metastatic at diagnosis | |||||||
| Yes | 96 (26.1%) | 155 (20.1%) | 658 (14.7%) | 831 (14.3%) | 146 (10.8%) | 6 (5.3%) | <0.001 |
| No | 233 (63.5%) | 557 (72.2%) | 3,406 (76.5%) | 4,430 (76.5%) | 1,038 (77.3%) | 89 (78.8%) | |
| Unknown | 38 (10.4%) | 60 (7.8%) | 387 (8.7%) | 528 (9.1%) | 159 (11.8%) | 18 (15.9%) | |
| Biopsy before | |||||||
| Yes | 299 (81.5%) | 555 (71.9%) | 763 (62.1%) | 3,690 (63.7%) | 906 (87.5%) | 72 (63.7%) | <0.001 |
| No | 35 (9.5%) | 162 (21.0%) | 1,365 (30.7%) | 1,644 (28.4%) | 346 (25.8%) | 32 (28.3%) | |
| Unknown | 33(9.0%) | 55 (7.1%) | 323 (7.3%) | 455 (7.9%) | 91 (6.8%) | 9 (8.0%) | |
| Imaging < surgery | |||||||
| Yes | 311 (84.7%) | 639 (82.8%) | 3,406 (76.5%) | 4,281 (74.0%) | 915 (68.1%) | 64 (66.6%) | <0.001 |
| No | 8 (2.2%) | 29 (3.8%) | 199 (4.5%) | 326 (5.8%) | 128 (9.5%) | 14 (12.4%) | |
| Unknown | 48 (13.1%) | 104 (13.5%) | 846 (19.0%) | 1,172 (20.2%) | 300 (22.3%) | 35 (31.0%) | |
| Neoadjuvant treat | |||||||
| Yes | 82 (22.3%) | 82 (10.6%) | 310 (7.0%) | 325 (5.6%) | 36 (2.7%) | 3 (2.7%) | <0.001 |
| No | 25 (6.8%) | 139 (18.0%) | 981 (22.0%) | 1,308 (22.6%) | 277 (20.6%) | 31 (27.4%) | |
| Total | 260 (70.8%) | 551 (71.4%) | 3,160 (71.0%) | 4,156 (71.8%) | 1,030 (76.7%) | 79 (69.9%) | |
| Surgery in NETSARC | |||||||
| Yes | 146 (39.8%) | 291 (37.7%) | 1,529 (34.4%) | 1849 (31.9%) | 351 (26.1%) | 16 (14.2%) | <0.001 |
| No/No surgery/UNK | 221 (60.2%) | 481 (62.3%) | 2,922 (65.6%) | 3,940 (68.1%) | 992 (73.9%) | 97 (85.8%) | |
| Excision margins of last surgery | |||||||
| R0 | 122 (33.2%) | 307 (39.8%) | 1,799 (40.4%) | 2,229 (38.5%) | 392 (29.2%) | 29 (25.7%) | <0.001 |
| R1 | 47 (12.5%) | 105 (13.6%) | 721 (16.2%) | 997 (17.2%) | 254 (18.9%) | 18 (15.9%) | |
| R2 | 9 (2.5%) | 42 (5.4%) | 197 (4.4%) | 235 (4.1%) | 58 (4.3%) | 7 (6.2%) | |
| Other/Unknown | 189 (51.5%) | 318 (41.2%) | 1,734 (38.9%) | 2,328 (40.2%) | 639 (47.6%) | 59 (52.2%) | |
Bold indicates significant p value (p < 0.05).
1
Chi2 test.