Table 3.

GSK3389404 Dose Proportionality Analysis Outcomes

Day (Dose Range)	N	PK Parameter	Slope Estimate	90%CI	Rsq
1 (10–120 mg)	40	AUC0‐24 (ng·h/mL)	1.08	0.98–1.18	0.8983
	40	AUC0‐∞ (ng·h/mL)	1.07	0.97–1.18	0.8903
	41	Cmax (ng/mL)	0.975	0.83–1.12	0.7771
22 (30–120 mg)	18	AUC0–τ (ng·h/mL)	1.25	1.04–1.46	0.8727
	18	Cmax (ng/mL)	1.25	0.96–1.55	0.7789

CI, confidence interval; N, total number of subjects; PK, pharmacokinetic; Rsq, coefficient of determination.