Table 5.
Interventions and outcome of first ALT elevationa
|
No intervention N = 61 |
Interventionb
N = 21 |
P | |
|---|---|---|---|
| First ALT > ULN, mean relative increase ± SD (min‐max relative increase) | 116% ± 19 (101%‐250%) | 269% ± 219 (110%‐800%) | <0.001 |
| Normalized ALT value, n (%) | 60 (98%) | 21 (100%) | 1.0 |
| Mean time to recorded normalized ALT value (min‐max), d | 93 (4‐1139) | 46 (11‐154) | 0.26 |
| New ALT > ULN, n (%) | 44/60 (73%) | 14/21 (67%) | 0.43 |
| Mean time to new recorded ALT > ULN (min‐max), d | 386 (7‐2136) | 121 (14‐364) | 0.12 |
ALT, alanine aminotransferase; SD, standard deviation; ULN, upper limit normal
a
Missing information in two patients
b
Interventions include further laboratory or radiographic investigation, dose reduction or temporary interruption of MTX or of other concomitant potentially liver‐toxic drugs