Table 6.

Patients who permanently stopped MTX due to ALT elevation

	Permanent cessation of MTX due to elevated ALT N = 7
Mean time to first ALT elevation from MTX start (min‐max), wk	57 (2‐107)
Mean time from MTX start to stopping MTX (min‐max), wk	99 (15‐258)
Relative ALT increase followed by permanent MTX cessation (min‐max)	260% (150%‐460%)
Normalized ALT after stopping MTX, n (%)	6 (86)a
Time to recorded normalized ALT after stopping MTX (min‐max), d	76 (8‐340)
New ALT > ULN after stopping MTX, n (%)	4/6 (67)
Time to new recorded ALT > ULN (min‐max), d	137 (7‐298)

ALT, alanine aminotransferase; MTX, methotrexate; ULN, upper limit normal

^aOne patient had persistent ALT elevation after stopping MTX and was later diagnosed with non‐alcoholic fatty liver disease