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. 2019 Apr 9;63(3-4):130–138. doi: 10.1111/1348-0421.12674

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© 2019 The Authors Microbiology and Immunology published by The Societies and John Wiley & Sons Australia, Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Antibody titers against four antigens are shown for all healthcare workers, except for those whose antibody titers were below the detection level. The cutoff values (dotted lines) for positivity were defined as two SDs above the mean titer in the group without Mtb infection. Arrow indicates an individual with preclinical TB. Numbers 1, 2, 3, and 4 indicate cases 1, 2, 3, and 4 in the recent LTBI group, respectively. In these five individuals, the antibody titers against ESAT6 (P = 0.03), Ag85A (P = 0.048), Acr (P = 0.057), and MDP1 (P = 0.0001) were significantly higher than those in the remote LTBI group [Color figure can be viewed at wileyonlinelibrary.com]