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Variation of the amine and aldehyde componentsa
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Conditions: 1 (1.0 mmol), amine (1.1 mmol), aldehyde (1.1 mmol), 4 Å mol sieves (1.0 g), CH2Cl2 (10.0 mL), rt, 18 h; then 2-ClPyr (1.2 mmol), Tf2O (1.1 mmol), −41 °C; then rt, 24 h. Isolated yield.
48 h for final step. c 2-FPyr used instead of 2-ClPyr.
