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Proposed rewired IA biosynthesis pathway in A. niger. MttA (mitochondrial tricarboxylate transporter) transports the TCA-cycle intermediate cis-aconitate from the mitochondrion into the cytosol where CadA (cis-aconitate decarboxylase) decarboxylates cis-aconitate and thereby forms itaconate. Itaconate is transporter over the cellular membrane by action of MfsA (major facilitator superfamily protein). CitB (cytosolic citrate synthase) catalyzes the synthesis of citrate in the cytosol
