Figure 2. Core temperature profile over 80 h for infants undergoing facilitated passive cooling (mean ± range).

A, rectal temperature of all infants over the first 80 h after birth. Passive HT is evident, with the nadir temperature at 15 h. The grey shaded area is the ‘normothermic’ range, whereas the blue line represents the target temperature for active therapeutic HT. Infants who died prior to discharge (B) and those with moderate and severe encephalopathy at day 4 (C) had deeper and more sustained HT. [Color figure can be viewed at wileyonlinelibrary.com]