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. 2019 Apr 21;597(14):3573–3585. doi: 10.1113/JP277767

Figure 2. Highlighting some of the important pathways in hepatic carbohydrate handling and de novo lipogenesis.

Figure 2

A, fructose is converted into fructose‐1‐phosphate via enzyme hepatic fructokinase. B, glucose is converted into glucose‐6‐phosphate via enzyme glucokinase. C, pyruvate is converted into acetyl‐coenzyme A via enzyme pyruvate dehydrogenase. D, acetyl coenzyme A is converted into malonyl coenzyme A via enzyme acetyl coenzyme A carboxylase, an enzyme which is negatively regulated by AMP‐activated protein kinase. F‐1‐P, fructose‐1‐phosphate; 6‐G‐P, glucose‐6‐phosphate; Acetyl‐CoA, acetyl coenzyme A; PDH, pyruvate dehydrogenase; ACC, acetyl CoA carboxylase; AMPK, AMP‐activated protein kinase; Malonyl‐CoA, malonyl coenzyme A.