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. 2019 Sep 29;18:1533033819871300. doi: 10.1177/1533033819871300

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Downregulation of ALDOA promotes migration of SW480 and SW620 cells. (A) SW480 cells were transfected with pcALDOA, negative control (pcDNA3.1), si-ALDOA and si-NC, and the transwell chamber assay performed to determine SW480 cell migration. (B) The same experiments as (A) were performed using SW620 cells. (C) Bar plot showing that downregulation of ALDOA promotes colon cancer SW480 cell proliferation. (D) Bar plot showing that miR-122 promotes colon cancer SW620 cell proliferation. Three and 5 replicate experiments were performed for transwell and MTT assays, respectively. (E) Proposed working model of the involvement of miR-122, ALDOA and other potential mRNA targets in the development of colon cancer.