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. 2019 Sep 24;11:8699–8710. doi: 10.2147/CMAR.S208508

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© 2019 Shao et al.

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TUG1 knockdown and miR-153-1 overexpression inhibit proliferation and invasion of CRC cells. (A) SW480 and HCT116 (data not shown) were transfected with si-NC or si-TUG1 and transfection efficiency was determined with qRT-PCR. (B–C) Colony formation and Wound healing assays were performed to measure the effect of TUG1 on the proliferation and invasion of CRC cells. (D) CCK-8 assay was performed to determine the viability of CRC cells. (E) SW480 and HCT116 (data not shown) were transfected with scramble or miR-153-1 mimic and transfection efficiency was determined with qRT-PCR. (F–G) Colony formation and wound healing assays were performed to measure the effect of miR-153-1 on the proliferation and invasion of CRC cells. (D) CCK-8 assay was performed to determine the viability of CRC cells. Values were expressed as mean ± SEM of three independent experiments. Data were collected from at least three independent experiments. ***P<0.001, **P<0.01.

Abbreviations: TUG1, taurine up-regulated 1; CRC, colorectal cancer.