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Hypertensive PAs produce greater contractile force with greater dependency on ROS. (A) PA from control (vehicle) and MCT rats were mounted on a myograph (1 g passive tension) and contracted with low-dose angiotensin II (100 nM). (B) Drop in tension following the addition of ROS scavenger TEMPOL (100 mM). n = 3–4, *p < 0.05. MCT, monocrotaline; PAs, pulmonary arteries; ROS, reactive oxygen species. Color images are available online.
