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. 2019 Sep 27;39(10):599–608. doi: 10.1089/jir.2019.0043

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© Ludmila Prokunina-Olsson 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 2. — Analysis of sequences from the IFNL4 and IFNL4-like regions. Shaded-nucleotides and amino acids that differ from the human IFNL4 sequence. Sequences from several species were retrieved from UCSC Browser and annotated using ClustalW alignment (http://www.ebi.ac.uk/Tools/msa/clustalo). Amino acid Y50 amino acid (TAC codon) is encoded by exon 1 of IFNL4 (upstream of IFNL3), whereas a similar sequence of the IFNL4-like region (upstream of IFNL2) encodes a stop codon (TAA), resulting in an invariable truncation of the putative IFN-λ4 protein after 49 aa. Sequences of the IFNL4-like region in other primates are more diverse and unlikely to encode any IFN-λ4-like protein fragments.