Table 3.
Combined Effects of IFNL4 Haplotypes on IFN-λ4 Activity and Hepatitis C Virus Clearance
| Ex 1 | 1000 Genomes Project populations | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ex 2 | rs368234815 | |||||||||
| P70S | Intr 1 | IFN-λ4/no IFN-λ4 | Upstream of IFNL4 | Outcome | East Asian N = 504 | European N = 503 | African N = 661 | |||
| Haplotypes | rs117648444, allele, aa | rs12979860 | rs11322783 | rs74597329 | rs8099917 | IFN-λ4 | HCV clearance | % | % | % |
| 1 | G | C | T | T | T | No | Best | 91.8 | 68.8 | 29.2 |
| 2 | A, 70S | T | — | G | T | Weak | Intermed | 0.5 | 11.8 | 7.5 |
| 3 | G, 70P | T | — | G | G | Strong | Worst | 7.5 | 16.4 | 4.2 |
| 4 | G, 70P | T | — | G | T | Strong | Worst | 0 | 2.6 | 55.07 |
| 5 | G, 70P | C | — | G | T | Strong | Worst | 0 | 0 | 3.8 |
Shaded—haplotypes associated with HCV clearance and functional effects on IFN-λ4 activity. rs8099917-T allele captures separation between no and weak versus strong IFN-λ4 activity but only in East Asians and most Europeans. In individuals of African ancestry, rs8099917 is excluded from the minimal common associated haplotype. 1000 Genomes Project populations are described in Fig. 1.