Figure 2.

Bexarotene reduces neurological impairment and relieves ischemia after SAH via PPARγ activation. (A) Modified Garcia scores. (B) Mortality. (C) Representative images of cerebral cortical blood flow detected using laser speckle and quantitative analysis of cortical cerebral blood flow. (D) SAH severity scores. (E) Brain water content in Sham group, SAH+vehicle group, SAH+bexarotene group, and SAH+bexarotene+GW9662 group (*p<0.05 versus SAH+vehicle group, ^# p<0.05 versus SAH+bexarotene group; n=12, with 12 used for modified Garcia scoring and SAH severity scoring and cerebral blood flow measurements and 4 used for brain water content). The same rats were used in Fig 2 and Fig 3 and belonged to experimental part 2.

PPARγ: peroxisome proliferator-activated receptor gamma; SAH: subarachnoid hemorrhage.