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. 2019 Jul 4;28(9-10):1242–1256. doi: 10.1177/0963689719857657

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 9. — Transmission electron microscopy of dermal–epidermal junction in engineered skin substitutes (ESS). Shown are images of ESS prepared with RDEB fibroblasts and keratinocytes (group 1; A–C), RDEB fibroblasts and normal keratinocytes (group 2; D–F), normal fibroblasts and RDEB keratinocytes (group 3; G–I), and normal fibroblasts and keratinocytes (group 4; J–L), as indicated, collected at the end of the in vitro incubation period (left; A, D, G, J), and at 2 weeks (center; B, E, H, K) and 3 weeks (right; C, F, I, L) after grafting. Anchoring fibrils appeared morphologically normal in samples of ESS prepared with all normal cells (J, K, L; small white arrows); anchoring fibrils in other samples, if present, appeared diffuse and without clear striations (black arrows). Hemidesmosomes were evident in vitro at 2 and 3 weeks in vivo (white asterisks). Original magnification was 80,000×; scale bar in A (200 nm) is the same for all sections.