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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Cell Calcium. 2019 Mar 23;80:18–24. doi: 10.1016/j.ceca.2019.03.006

Fig. 1.

Fig. 1.

Deletion of mir-204 increases contractile response and IP3R1 expression in aorta. (A–E) Contractile response to phenylephrine (PE) (A), thromboxane analogue (U46619) (B), endothelin-1 (ET-1) (C), angiotensin-II (Ang II) (D) and norepinephrine (NE) (E) in aortas of miR-204−/− and WT mice. *p < 0.05 vs WT. Inhibition of IP3R1 with 2-aminoethoxydiphenyl borate (2-APB) (50 μm) suppresses vasoconstriction to all agonists in both groups, without any difference between them (Fig. 1A–E). ^p < 0.05 vs WT + 2-APB. (F–G) Immunoblots for IP3R1 (F) with quantification (G) in aortas of miR-204−/− and WT mice. *p < 0.05 vs WT. (H) qRT-PCR for IP3R1 in aortas of miR-204−/− mice and WT mice. *p < 0.05 vs WT.