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A5-HT2C agonists pEC50 and Emax values, relative to 5-HT: β-arrestin recruitment.
| Agonist | pEC50 | Emax (% 5-HT) |
|---|---|---|
| lorcaserin | 6.93 ± 0.04a | 118 ± 5a |
| 5-HT | 8.21 ± 0.08 | 100 ± 6 |
| Ro 60–0175 | 7.86 ± 0.11 | 92 ± 4 |
| MBP | 6.84 ± 0.10a | 7 ± 4a |
| aripiprazole | < 6a | 8 ± 1a |
n = 3.
= P < 0.05 different from 5-HT via one-way ANOVA.
