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Schematic model of calcium-sensing receptor and selected downstream pathways.
AP2: Adaptor Protein 2, β-arrestin, Ca2+: Calcium ion, CaSR: Calcium-Sensing Receptor, DAG: Diacylglycerol, GDPαβγ: G-protein, PLC-β: Phospholipase C β, PKC: Protein kinase C, P: Phosphothreonine, IP3: Inositol triphosphate.
FHH: Familial Hypocalciuric Hypercalcemia, CASR: Calcium-sensing receptor gene, GNA11: G Protein Subunit Alpha 11 gene, AP2S1: Adaptor Related Protein Complex 2 Sigma 1 Subunit gene.
