Table 1.
Clinical characteristics and complement factors levels of normal nonpregnant women and normal pregnant women.
| variable | Nonpregnancy | Early pregnancy | Middle pregnancy | Late pregnancy | P value |
|---|---|---|---|---|---|
| Age, y | 30±4 | 32±4 | 31±3 | 31±4*** | 0.514 |
| Nulliparous, n, % | – | 18 (60) | 21 (70) | 21 (70)*** | 0.796 |
| Gravidity | – | 2 (2–3) | 2 (2–3) | 2 (1–3) | 0.436 |
| Parity | – | 0 (0–1) | 0 (0–1) | 0 (0–1) | 0.524 |
| Gestational age, weeks | – | 11.0±2.1 | 24.2±2.2 | 30.1±2.8 | – |
| BMI, kg/m2 | 22.7 (19.8–26.4) | 23.6 (20.1–26.7) | 22.3 (19.1–25.4) | 20.9 (19.5–22.6)*** | 0.260 |
| Systolic BP, mmHg | 114 (93–106) | 115 (108–120) | 109 (98–115) | 117 (111–127)*** | 0.38 |
| Diastolic BP, mmHg | 75 (71–82) | 72 (65–78) | 68 (63–71) | 71 (61–80)*** | 0.42 |
| C1q, μg/mL | 196 (180–225) | 174 (163–204) | 190 (172–208) | 187 (174–223)*** | 0.060 |
| Bb, ng/mL | 408 (302–480) | 430 (371–468) | 410 (327–478) | 403 (350–452)*** | 0.250 |
| H, μg/mL | 314 (279–339) | 337 (296–374) | 385 (343–412)*,** | 370 (350–410)*,**,*** | <0.001 |
| C3, μg/mL | 1016 (905–1125) | 1103 (1010–1184)* | 1402 (1275–1528)** | 1438 (1285–1599)*** | <0.001 |
| C4, μg/mL | 187 (159–213) | 221 (201–251)* | 229 (172–289) | 223 (197–267)*** | 0.006 |
Non-normally distributed data are listed as median (IQR), normally distributed data are listed as mean ±SD.
*
Compared with NP, p<0.05;
**
compared with EP, p<0.05;
***
compared with MP, p>0.05;
‘−‘ – not applicable.