Table 2.
Distribution of Plasma Fluconazole Concentrations and Proportion Achieving Therapeutic Concentrations
| Fluconazole Dose | 100 mg | 200 mg | 400 mg | 800 mg | 1200 mg | 1600 mg | 2000 mg |
|---|---|---|---|---|---|---|---|
| Mean plasma concentration (±SD), µg/mL | 5.3 ± 2.7 | 10.7 ± 5.3 | 21.3 ± 10.7 | 42.6 ± 21.3 | 63.9 ± 31.9 | 85.2 ± 42.6 | 106 ± 53 |
| % below MIC | 39.8% | 20.7% | 8.8% | 3.3% | 1.7% | 1.1% | 0.8% |
| Mean AUC24 (±SD) mg*h/L | 127.8 ± 63.9 | 255.6 ± 127.8 | 511.2 ± 255.6 | 1022.4 ± 511.2 | 1533.6 ± 766.8 | 2044.8 ± 1022.4 | 2556 ± 1278 |
| % AUC:MIC > 100 | 13.4% | 30.6% | 53.2% | 74.2% | 83.3% | 88.3% | 91.2% |
| % AUC:MIC > 389 optimal | 1.5% | 6.1% | 17.2% | 36.3% | 49.7% | 59.2% | 66.1% |
Abbreviations: AUC, area under the curve; MIC, minimum inhibitory concentration; SD, standard deviation.