Table 2.
Pathologic features of surgical resections and mutational analysis of cystic fluid and neoplastic tissue
| Final diagn-osis | Pat. code | Gender | Age | Status | Sample |
Proportion of mutated allele |
Patholo-gical feature-s | |||||||
| KRAS | GNAS | TP53 | RAF1 | PTPRD | CTNNB1 | RNF43 | POLD1 | |||||||
| Cancer | 1 | F | 73 | No mutatio-n | CF | - | - | - | - | - | - | - | - | MCN with invasive ADK |
| NT | - | - | - | - | - | - | - | - | ||||||
| Cancer | 9 | M | 72 | Noncon-cordant mutatio-ns | CF | 0 | - | - | 0 | 0 | - | - | - | IPMN with invasive adenoca-rcinoma pT2N1 |
| NT | 100 | - | - | 26 | 100 | - | - | - | ||||||
| Cancer | 10 | F | 60 | Conc-ordant mutatio-ns | CF | 5 | - | - | - | - | - | - | 50 | IPMN with invasive adenoca-rcinoma pT3N1 |
| NT | 0 | - | - | - | - | - | - | 24 | ||||||
| Cancer | 13 | M | 66 | Concor-dant mutatio-ns | CF | 3 | - | 1 | - | - | - | - | - | IPMN with invasive adenoca-rcinoma pT3N1 |
| NT | 35 | - | 22 | - | - | - | - | - | ||||||
| Cancer | 14 | M | 63 | Concor-dant mutatio-ns | CF | - | 37 | - | - | - | - | - | - | MCN with invasive ADK |
| NT | - | 19 | - | - | - | - | - | - | ||||||
| Cancer | 15 | M | 83 | Concor-dant mutatio-ns | CF | 32 | 50 | - | - | - | - | - | - | IPMN with focal adenoca-rcinoma pTisN0 |
| NT | 9 | 19 | - | - | - | - | - | - | ||||||
| Cancer | 17 | F | 71 | Concor-dant mutatio-ns | CF | 25 | 48 | - | - | - | 56 | - | - | IPMN with focal adenoca-rcinoma pTisN0 |
| NT | 21 | 42 | - | - | - | 37 | - | - | ||||||
| Cancer | 18 | M | 82 | Concor-dant mutatio-ns | CF | 41 | - | - | - | - | - | 39 | - | IPMN with focal adenoca-rcinoma pTisN0 |
| NT | 32 | - | - | - | - | - | 35 | - | ||||||
| Cancer | 19 | F | 67 | Concor-dant mutatio-ns | CF | 23 | - | 31 | - | - | - | - | - | MCN with invasive ADK |
| NT | 0 | - | 18 | - | - | - | - | - | ||||||
| NO Cancer | 2 | M | 86 | No mutatio-n | CF | - | - | - | - | - | - | - | - | IPMN with low-grade dysplasi-a |
| NT | - | - | - | - | - | - | - | - | ||||||
| NO Cancer | 3 | M | 75 | No mutatio-n | CF | - | - | - | - | - | - | - | - | Serous cystaden-oma |
| NT | - | - | - | - | - | - | - | - | ||||||
| NO Cancer | 4 | F | 66 | No mutatio-n | CF | - | - | - | - | - | - | - | - | IPMN with low-grade dysplasi-a |
| NT | - | - | - | - | - | - | - | - | ||||||
| NO Cancer | 8 | F | 81 | No mutatio-n | CF | - | - | - | - | - | - | - | - | Mucinou-s cystaden-oma |
| NT | - | - | - | - | - | - | - | - | ||||||
| NO Cancer | 16 | M | 63 | No mutatio-n | CF | - | - | - | - | - | - | - | - | Cystic lymphan-gioma |
| NT | - | - | - | - | - | - | - | - | ||||||
| NO Cancer | 6 | M | 71 | Nonconc-ordant mutatio-ns | CF | 12 | 31 | - | - | - | - | - | - | IPMN with low-grade dysplasi-a |
| NT | 0 | 0 | - | - | - | - | - | - | ||||||
| NO Cancer | 5 | M | 74 | Concor-dant mutatio-ns | CF | 41 | 12 | - | - | - | - | - | - | IPMN with low-grade dysplasi-a |
| NT | 31 | 0 | - | - | - | - | - | - | ||||||
| NO Cancer | 20 | M | 51 | Concor-dant mutatio-ns | CF | - | 26 | - | - | - | - | - | - | IPMN with low-grade dysplasi-a |
| NT | - | 7 | - | - | - | - | - | - | ||||||
ADK: Adenocarcinoma; CF: Cystic fluid; IPMN: Intraductal papillary mucinous neoplasm; LGD: Low-grade dysplasia; MCN: Mucinous cystadenoma; NT: Neoplastic tissue; pTis: Carcinoma in situ, invasion of lamina propria.