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. 2019 Sep 23;10:1080. doi: 10.3389/fphar.2019.01080

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Copyright © 2019 He, Guo, Zhao, Meng, Chen, Ren, Pan, Fan, Jiang, Qin, Zhu and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHI-C4 improved perfusion of ischemic limbs and enhanced local angiogenesis in ischemic mice in vivo. (A) Representative images of laser Doppler perfusion analysis for control mice and mice treated with DHI-C4 before surgery and at different time points after surgery (n = 3). (B) The mean hindlimb blood flow was calculated as the ratio of ischemic side to non-ischemic side. DHI-C4 significantly improved perfusion recovery after HLI surgery at 21 days. *P < 0.05, DHI-C4 group compared with the control group. (C) Representative bioluminescent images of VEGFR-2-Luc mice after HLI were obtained at 18, 21, and 27 days under the same imaging conditions. (D) Representative images of micro-CT reconstructed 3D microangiography of the defect areas (n = 3).