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. 2018 Dec 4;12:128. doi: 10.1186/s13065-018-0497-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 29 — a, b Binding models of the synthesized compounds in AChE and BuChE enzymes active sites. Yellow dashed lines in (a) showing hydrogen bonding between Tyr146 and one of thioureas hydrogen atom from different compounds [48]