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. 2018 Dec 4;12:128. doi: 10.1186/s13065-018-0497-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Scheme 1 — Synthesis of the studied coumarin compounds (C87_G–N). Reagents: (a) HBr; (b) 2-(Boc-amino)ethyl bromide; (c) CF₃COOH; (d) DCC, (3,5-difluorophenyl)acetic acid, 3,5-difluorocinnamic acid, 3,4-difluorodihydrocinnamic acid or 3,4-dichlorocinnamic acid [15]