Table 1:
Characteristics of DEFUSE 3 Non-Dawn Core-Too-Large (CTL) versus all DEFUSE 3 Core Not Too Large (CNTL) Patients
| Baseline | CTL (N=33) | DEFUSE 3 CNTL (N=149) | p-value |
|---|---|---|---|
| Age- median (IQR) Age ≥80yrs- n(%) |
72 (58–83) 14 (42) |
70 (60–78) 32 (21) |
0.512 0.016 |
| Male- n(%) | 19 (58) | 71 (48) | 0.302 |
| NIHSS- Median (IQR) | 18 (14–21) | 15 (11–20) | 0.174 |
| Wake-up Stroke- n(%) Witnessed onset- n(%) Unwitnessed onset- n(%) |
17 (52) 9 (27) 7 (21) |
74 (50) 57 (38) 18 (12) |
0.278 |
| tPA treatment- n(%) | 6 (18) | 12 (8) | 0.103 |
| Randomized to intervention- n(%) | 18 (55) | 74 (50) | 0.612 |
| Imaging | |||
| Imaging with MRI/MRP- n (%) | 10 (30) | 39 (26) | 0.6285 |
| ASPECTS on baseline CT- median (IQR) | 7 (7–9) | 8 (7–9) | 0.020 |
| ICA Occlusion- n(%) | 14 (42) | 54 (36) | 0.507 |
| Good collaterals on CTA- n(%) | 10 (45) | 87 (81) | <0.001 |
| Ischemic core volume, ml- median(IQR) Perfusion lesion volume, ml- median (IQR) |
45.2 (37.6–60.4) 145.8 (127.3–184.7) |
7.3 (0–13.9) 98.7 (67.5–144.4) |
<0.001 <0.001 |
| Time and Process (in HH:MM) | |||
| Onset to imaging- median (IQR) | 9:08 (7:02–11:09) | 10:24 (8:23–12:17) | 0.030 |
| Imaging to puncture- median (IQR) | 0:54 (0:36–1:34) | 0:59 (0:41–1:20) | 0.957 |
| Puncture to reperfusion- median (IQR) | 0:36 (0:27–0:55) | 0:40 (0:27–1:00) | 0.635 |
| Onset to reperfusion- median (IQR) | 11:44 (10:14–13:05) | 12:19 (9:44–13:42) | 0.601 |
| Outcomes | |||
| Functional independence at 90 days- n(%) | 8 (24) | 48 (32) | 0.369 |
| mTICI 2b/3- n(% of endovascular patients) | 16 (89) | 54 (73) | 0.222 |
| Infarct volume at 24hrs- median (IQR) | 119.0 (74.6–180.0) | 31.5 (17.6–64.3) | <0.001 |
| Infarct growth- median (IQR) | 83.9 (39.4–135.8) | 23.8 (11.7–51.1) | <0.001 |
| Reperfusion >90% at 24hrs- n(%) | 13 (50) | 58 (50) | 1.0 |
| Complete recanalization on MRA/CTA- n(%) | 13 (50) | 66 (49) | 0.945 |
| Reperfusion >90% at 24hrs and/or complete recanalization on MRA/CTA – n(%) | 13 (48) | 67 (49) | 0.970 |
| Safety | |||
| Death at 90 days- n(%) | 6 (18) | 30 (20) | 0.799 |
| Symptomatic intracranial hemorrhage- n(%) | 3 (9) | 7 (5) | 0.391 |
| Parenchymal hematoma type 2- n(%) | 2 (6) | 9 (6) | 1.0 |
| Early neurological deterioration- n(%) | 3 (9) | 17 (11) | 0.774 |
Notes: ASPECTS: N=115 & 27; Perfusion lesion volume: N=147 & 33; Good collaterals (modified Tan method, CTA only): N= 22 & 108; Imaging to puncture- median: N=74 & 18; Puncture to reperfusion: N=64 & 16; Onset to reperfusion: N=64 & 16; Infarct volume at 24hrs: N=147 & 32; Infarct growth: N=147 & 32; mTICI 2b/3: N=74 & 18; Reperfusion >90% at 24hrs: N=116 & 26; Complete recanalization on MRA/CTA: N=134 &26; Reperfusion >90% at 24hrs and/or complete recanalization on MRA/CTA: N=138 & 27