Table 1. Temporal changes in mean arterial blood pressure (MABP), PaCO2, and PaO2 in rats.
Relative to baseline, mean arterial blood pressure (MABP), arterial partial pressure of CO2 (PaCO2), and arterial partial pressure of O2 (PaO2) were not significantly different over time in rats that did not receive hypoxia (p > 0.05). As expected PaO2 significantly decreased during hypoxia exposure (P < 0.05), but returned to baseline values following exposure. Rat groups treated with intermittent or sustained hypoxia showed similar significant decreases in MABP during hypoxia (p < 0.05) and small but significant decreases in MABP 60 min post-hypoxia compared to baseline (p < 0.05). Overall, there was not a significant treatment effect on MABP (p > 0.05).
| Treatment | N | Baseline | 1st HX | 60 min post |
|---|---|---|---|---|
| 112 ± 5 (MABP) | 112 ± 5 | 105 ± 5 | ||
| No hypoxia | 14 | 47.7 ± 1.2 (PaCO2) | 47.7 ± 1.2 | 47.6 ± 1.2 |
| 267.2 ± 4.0 (PaO2) | 265.9 ± 4.7 | 252.2 ± 8.7 | ||
| 112 ± 5 | 68 ± 4* | 105 ± 4* | ||
| Intermittent hypoxia | 9 | 45.2 ± 1.2 | 44.0 ± 1.7 | 45.9 ± 1.1 |
| 275.7 ± 6.5 | 38.9 ± 0.8* | 262.0 ± 8.1 | ||
| 110 ± 4 | 65 ± 7* | 100 ± 3* | ||
| Sustained hypoxia | 14 | 44.4 ± 1.8 | 43.9 ± 0.8 | 44.0 ± 0.9 |
| 257.0 ± 4.9 | 37.9 ± 1.2* | 245.4 ± 8.0 | ||
*
Significantly different from baseline within treatment group