Skip to main content
. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Nat Med. 2019 Jul 8;25(8):1274–1279. doi: 10.1038/s41591-019-0492-5

Figure 1. Discovery study design for the peripheral artery disease genome-wide association analysis.

Figure 1.

Electronic health record based phenotyping identified 31,307 PAD cases of varying severity, as depicted in the upper row of boxes, in the Million Veteran Program. The association of DNA sequence variants with PAD was tested separately in 3 mutually exclusive ancestry groups and the results combined using an inverse-variance weighted fixed effects meta-analysis in the discovery phase. Variants with suggestive association (two-sided logistic regression P < 10−6) were then brought forward for independent replication in the UK Biobank.

Abbreviations: GWAS, genome-wide association study; PAD, Peripheral Artery Disease