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. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Nat Med. 2019 Jul 8;25(8):1274–1279. doi: 10.1038/s41591-019-0492-5

Extended Data Figure 7 -.

Extended Data Figure 7 -

Peripheral artery disease risk variants and association with LAS and CAD

For the 19 PAD risk variants identified in our study, logistic regression Z-scores of association (aligned to the PAD risk allele) were obtained from MVP and publicly available summary statistics for large artery stroke (MVP + MEGASTROKE consortium2) and coronary artery disease (MVP + CARDIoGRAMplusC4D consortium3). A positive Z-score (red) indicates a positive association between the PAD risk allele and the disease, while a negative Z-score (blue) indicates an inverse association. Boxes are outlined in cyan if the variant is uniquely associated with PAD (two-sided PPAD < 5 ×10−8, PCAD & PLAS > 0.05).

Abbreviations: PAD, Peripheral Artery Disease; LAS, Large Artery Stroke; CAD, Coronary Artery Disease