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. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Nat Med. 2019 Jul 8;25(8):1274–1279. doi: 10.1038/s41591-019-0492-5

Figure 2. Representative heatmap of phenome-wide association results and biologic pathways underlying genetic loci associated with peripheral artery disease.

Figure 2.

Logistic regression Z-scores (aligned to the PAD risk allele) from the MVP PheWAS analysis (N = 176,913) or publically available PheWAS results from PhenoScanner 2.0 (variable N, see Supplementary Table 23) are shown for the associations between the 19 PAD risk loci and representative disease traits. A positive Z-score (red) indicates a positive association between the PAD risk allele and the disease, whereas a negative Z-score (blue) indicates an inverse association. Boxes are outlined in cyan if the variant is associated with the indicated disease at genome-wide significance (logistic regression two-sided P < 5.0 ×10−8).

Abbreviations: COPD, chronic obstructive pulmonary disease; SLE, Systemic Lupus Erythematosus