Skip to main content
. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Nat Med. 2019 Jul 8;25(8):1274–1279. doi: 10.1038/s41591-019-0492-5

Figure 3. Factor V Leiden mutation and vascular disease.

Figure 3.

(a–d) The association of the thrombophilic Factor V Leiden variant, F5 p.R506Q, with different types of vascular disease were analyzed, as depicted in forest plots. Associations are shown with CAD (a) and LAS (b) using MVP and GWAS meta-analysis data (either CARDIoGRAM plusC4D or MEGASTROKE, respectively) that was combined using an fixed-effects, inverse-variance weighted meta-analysis. Associations with all PAD cases, as well as PAD cases of increasing severity (c), and PAD cases stratified by smoking status (d) among European ancestry MVP participants are shown. Two-sided logistic regression P values are displayed. Gray boxes reflect the inverse-variance weight for each study or subgroup.

Abbreviations: CI, Confidence Interval; CAD, Coronary Artery Disease; LAS, Large Artery Stroke; PAD, Peripheral Artery Disease; MVP, Million Veteran Program; GWAS, Genome-wide Association Study