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. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Nat Med. 2019 Jul 8;25(8):1274–1279. doi: 10.1038/s41591-019-0492-5

Extended Data Figure 4 -.

Extended Data Figure 4 -

TCF7L2 mediates its effect on PAD via type 2 diabetes

a) Forest plot depicting the replication of the known TCF7L2/rs7903146-T2D association signal in MVP for both white and black participants. b) The same variant is also associated with PAD risk in whites and blacks in MVP. However, when controlling for T2D status in the regression model, c) the association signal is dramatically reduced suggesting that TCF7L2 PAD risk is mediated through its effect on T2D. Logistic regression two-sided values of P are displayed.

Abbreviations: MVP, Million Veteran Program; PAD, Peripheral Artery Disease; T2D, Type 2 Diabetes